The Browns will have to dig deep and embrace the "next man up" mantra at multiple positions Sunday in Jacksonville.
In addition to the five players on the reserve/COVID-19 list, the Browns on Friday listed two players as out and two others as questionable for their Week 12 matchup with the Jaguars.
CB Denzel Ward (calf) did not practice this week and will miss his first game of the season. S Sheldrick Redwine (knee) will also be sidelined after not practicing this week.
S Andrew Sendejo (groin), G Wyatt Teller (calf) and C Nick Harris (ankle) are considered questionable. Teller, who was a limited participant throughout the week, was listed as questionable last week but played every snap. Sendejo did not practice Wednesday and Thursday but was limited Friday. Harris was added to the injury report after Friday's practice.
The Browns will also be without five players who are on the reserve/COVID-19 list: DE Myles Garrett, FB Andy Janovich, DE Joe Jackson, DE Porter Gustin and LB Sione Takitaki.
"Our guys throughout this season have understood that they have to have a laser focus every single day to be able to prepare," Browns coach Kevin Stefanski said. "We are not concerned with anything that may attempt to distract us. We really have a task at hand and the guys have remained focused on that."
Check out exclusive photos of the Browns preparing for their game against the Jacksonville Jaguars

Wide receiver Jarvis Landry (80) during practice on November 25, 2020

Wide receiver KhaDarel Hodge (12) during practice on November 25, 2020

Linebacker Montrel Meander (41) during practice on November 25, 2020

Defensive tackle Jordan Elliott (90) during practice on November 25, 2020

Defensive tackle Jordan Elliott (90) during practice on November 25, 2020

Defensive end Cameron Malveaux (69) during practice on November 25, 2020

Cornerback Kevin Johnson (28) during practice on November 25, 2020

Safety Ronnie Harrison (33) during practice on November 25, 2020

Defensive tackle Jordan Elliott (90) during practice on November 25, 2020

Defensive end Porter Gustin (97) during practice on November 25, 2020

Wide receiver Jarvis Landry (80) during practice on November 25, 2020

Defensive tackle Sheldon Richardson (98) during practice on November 25, 2020

Cornerback Kevin Johnson (28) during practice on November 25, 2020

Defensive tackle Sheldon Richardson (98) during practice on November 25, 2020

Offensive tackle Jack Conklin (78) during practice on November 25, 2020

Defensive tackle Sheldon Richardson (98) during practice on November 25, 2020

Head Coach Kevin Stefanski during practice on November 25, 2020

Quarterback Baker Mayfield (6) during practice on November 25, 2020

Linebacker B.J. Goodson (93) during practice on November 25, 2020

Wide receiver Donovan Peoples-Jones (11) during practice on November 25, 2020

Offensive guard Wyatt Teller (77) during practice on November 25, 2020

Center JC Tretter (64) during practice on November 25, 2020

Quarterback Baker Mayfield (6) during practice on November 25, 2020

Wide receiver Donovan Peoples-Jones (11) during practice on November 25, 2020

Quarterback Baker Mayfield (6) during practice on November 25, 2020

Wide receiver Rashard Higgins (82) during practice on November 25, 2020

Running Back Nick Chubb (24) during practice on November 25, 2020

Wide receiver Jarvis Landry (80) during practice on November 25, 2020

Quarterback Baker Mayfield (6) during practice on November 25, 2020

Running Back Kareem Hunt (27) during practice on November 25, 2020

Tight end Austin Hooper (81) during practice on November 25, 2020

Fullback Johnny Stanton (43) during practice on November 25, 2020

Quarterback Baker Mayfield (6) during practice on November 25, 2020