The Browns on Tuesday placed center Nick Harris and guard Dawson Deaton on injured reserve, ending their seasons.
Harris, a third-year veteran, suffered a right knee injury Friday on the second play of the Browns' preseason game in Jacksonville. He was expected to be the Browns' starting center in 2022.
Deaton, a seventh-round rookie from Texas Tech, was carted off the field in Monday's practice.
The Browns' remaining centers on the roster include Ethan Pocic, who has taken first-team reps since Harris' injury, and Brock Hoffman, an undrafted rookie from Virginia Tech.